Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela베네수엘라에서 SARS-CoV-2에 대한 관심 및 우려의 변종에 대한 1년 연속 설명Article Published on 2022-06-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha VOC antibody Antibody-mediated neutralization circulating Complete concern correlation country COVID-19 Delta Delta VOC description dissemination Frequency Gamma Genome sequencing genomic interest Lambda less Lineage lineages low frequency MONITOR Mutation mutations neutralization New coronavirus omicron predominant rapid screening. responsible SARS-CoV-2 sequenced Transmissibility variant variants variants of concern Venezuela VoC VOCs VOI VOIs WHO [DOI] 10.3390/v14071378 PMC 바로가기 [Article Type] Article
Low frequency of SARS-CoV2 infection in daycare centers during the reopening of school activities in the Southeast’s poor area of Brazil브라질 남동부 빈곤지역 등교 재개시 어린이집 SARS-CoV2 감염빈도 낮음Article Published on 2022-06-242022-09-11 Journal: Revista do Instituto de Medicina Tropical de São [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] activity age Asymptomatic average average age Brazil caused children collected conducted country death deaths Effectiveness female health authorities Health authority highest indicate lack low frequency Mortality nasopharynx occurred outbreak P.1 pandemic Participants positive Prevalence preventive measure purification rates of infection reopening return RNA extraction SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection Secondary infection secondary infections Seven study population swab samples took place Transmission vaccination Vaccine variant Viral RNA was obtained [DOI] 10.1590/S1678-9946202264046 PMC 바로가기 [Article Type] Article
Regional and temporal coordinated mutation patterns in SARS-CoV-2 spike protein revealed by a clustering and network analysis클러스터링 및 네트워크 분석에 의해 밝혀진 SARS-COV-2 스파이크 단백질의 지역 및 시간적 조정 돌연변이 패턴Article Published on 2022-01-212022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 치료기술, [키워드] antibody applied automated circulating Cluster Clustering Computational biology and bioinformatics Convalescent patients correlated country detect Evolution Frequency GISAID database group higher infectivity immunology low frequency mutated Mutation mutations network analysis neutralization occur Regional regions SARS-CoV-2 SARS-CoV-2 spike protein sequence sera Spike protein Spread strain Strains the SARS-CoV-2 Treatment vaccinated individual vaccinated individuals Vaccine design variant variants VoC VOCs while WHO [DOI] 10.1038/s41598-022-04950-4 PMC 바로가기 [Article Type] Article
Low frequency of disease flare in patients with rheumatic musculoskeletal diseases who received SARS-CoV-2 mRNA vaccineResearch Article Published on 2022-01-112022-10-28 Journal: Arthritis Research & Therapy [Category] COVID-19, SARS, [키워드] adverse event anti-SARS-CoV-2 connective tissue Control control group controls COVID-19 disease dose evaluated event example female Fever first dose Follow-up Frequency healthy control immunization immunosuppressants incidence rate Inflammatory arthritis inhibitor injection investigated joint Local Logistic regression analysis low frequency males median median age Mild MOST mRNA vaccine Musculoskeletal occurred Occurrence Pain Patient patients pauci-symptomatic performed psoriatic arthritis reactogenicity remained reported Result Rheumatic musculoskeletal disease rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 vaccination second dose subject supplementary material Symptom therapy Treatment vaccination Vaccine vaccine administration was recorded women [DOI] 10.1186/s13075-021-02674-w PMC 바로가기 [Article Type] Research Article
A low-cost TaqMan minor groove binder probe-based one-step RT-qPCR assay for rapid identification of N501Y variants of SARS-CoV-2SARS-CoV-2의 N501Y 변이체를 신속하게 식별하기 위한 저비용 TaqMan 작은 홈 결합제 프로브 기반 1단계 RT-qPCR 분석Article Published on 2022-01-012022-09-11 Journal: Journal of virological methods [Category] SARS, 변종, 치료기술, [키워드] Accuracy allele frequency analytical sensitivity B.1.1.7 B.1.351 collected COVID-19 detect determine diagnostic Diagnostic accuracy evaluated expand Frequency Genome Genome sequencing gold gold standard health authorities house identify in some Lineage low frequency Mutation N501Y N501Y mutation N501Y variants One-step RT-qPCR positive Prevalence qPCR qPCR assay reduced reference standard respiratory specimen respiratory specimens robust RT-qPCR SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing Surveillance TaqMan time-consuming Transmissibility variant Variant of concern. variants variants of concern variants of SARS-CoV-2 whole-genome sequencing widespread wildtype [DOI] 10.1016/j.jviromet.2021.114333 PMC 바로가기 [Article Type] Article
Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals전염병 및 COVID-19 회복기 개인의 교차 반응성 및 단일 반응성 SARS-CoV-2 CD4+ T 세포Research Article Published on 2021-12-292022-09-10 Journal: PLoS Pathogens [Category] SARS, 치료기술, 치료법, [키워드] Activation allele Amino acid amino acid sequence Amino acid sequences analysis assays Author CD4+ T cell class common cold common cold coronavirus common cold Coronaviruses common cold virus common cold viruses contributed convalescent convalescent individual convalescent individuals coronavirus coronavirus COVID-19 cross-react cross-reactive cross-reactivity defined demonstrated Direct dominant epitope DPB1 elicit elicited Endemic epitope Epitopes Ex vivo frequencies Frequency functional HLA-DP HLA-DR identify immunodominant low frequency marker membrane MHC-II naïve individuals nucleocapsid Nucleocapsid proteins overlapping PBMC peptide peptides Potential prevalent Previous studies previous study proportion protective immunity Protein reactive reagent recognizing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 epitope SARS-CoV-2 epitopes sequence identity shown spike staining stratified subjects suggested T cell T cell epitope T cell epitopes T cell response T cell responses T cells the Spike to define unlikely viruses was used were used world population [DOI] 10.1371/journal.ppat.1010203 PMC 바로가기 [Article Type] Research Article
Systematic review and meta-analysis of the safety of chloroquine and hydroxychloroquine from randomized controlled trials on malarial and non-malarial conditions말라리아 및 비 말라리아 조건에 대한 무작위 대조 시험에서 클로로퀸 및 하이드 록시 클로로 퀴인의 안전성에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-11-042022-09-10 Journal: Systematic Reviews [Category] SARS, 임상, [키워드] 95% confidence interval adverse effects adverse event applied assessment cardiac complication Cardiac complications CENTRAL certainty certainty of evidence Chloroquine clinical trials condition conditions coronavirus coronavirus disease COVID-19 development Effectiveness evaluate event rate event rates frequencies Frequency HCQ Hydroxychloroquine incidence increase LILACS low frequency malarial management meta-analyses Meta-analysis moderate no significant difference objective Odds ratio Participants patients with COVID-19 Placebo Primary outcome Primary outcomes random-effects model randomized clinical trial Randomized controlled trial RCT RCTs remained Result retinopathy SAE SAEs Safety Serious Adverse Event Serious Adverse Events supplementary material systematic review trials were excluded [DOI] 10.1186/s13643-021-01835-x PMC 바로가기 [Article Type] Meta-Analysis
Low frequency of community-acquired bacterial co-infection in patients hospitalized for COVID-19 based on clinical, radiological and microbiological criteria: a retrospective cohort studyResearch Published on 2021-10-302022-10-28 Journal: Antimicrobial Resistance and Infection Control [Category] COVID-19, MERS, SARS, [키워드] Admission antibiotic antibiotic use Antibiotics Antimicrobial stewardship antimicrobial use bacterial co-infection categories Characteristics Chest computed tomography Clinical characteristics Co-infection Cohort community-acquired pneumonia Complete conducted COVID-19 COVID-19 patient COVID-19 patients defined diagnostic protocol drug Frequency Hospital admission Inconclusive inflammatory markers low frequency parameter Patient patients hospitalized patients with COVID-19 positive SARS-CoV-2 PCR radiological recommendation Reporting Result retrospective cohort study Retrospective study SARS-CoV-2 study population supplementary material System unlikely [DOI] 10.1186/s13756-021-01024-4 PMC 바로가기 [Article Type] Research
In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2remdesivir 저항의 시험 관내 선택 SARS-COV-2의 진화 적 예측 가능성을 시사한다.Research Article Published on 2021-09-172022-08-13 Journal: PLoS Pathogens [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] absence accumulation acting Affect animal model animal models Antiviral antiviral drug approved Author backbone changes in characterisation circulating SARS-CoV-2 variant Clinical management conserved coronavirus COVID-19 patients displaying drug-resistant EIDD2801 Evidence evidence of excess FDA FDA approval Frequency genetics immune immune pressure immune selection implication in vitro indicate low frequency morbidity and mortality mutants Mutation no evidence of not affect Nsp12 nucleoside occurred overcome passage patients polymerase Population predicted provide RDV Remdesivir replication advantage residue resistant mutants responsible risk RNA virus RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants selected sensitivity Sequencing single mutation small molecule Substitution substitutions Surveillance the SARS-CoV-2 genome Transmission Treatment treatment of COVID-19 patients variants of concern Viral viral replication virus virus viruses widespread worldwide pandemic [DOI] 10.1371/journal.ppat.1009929 PMC 바로가기 [Article Type] Research Article
Ahead of the second wave: Early warning for COVID-19 by wastewater surveillance in Hungary두 번째 물결을 앞두고: 헝가리의 폐수 감시를 통한 COVID-19 조기 경보Article Published on 2021-09-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] average Budapest Capital comparable Concentration correlated correlation COVID-19 COVID-19 outbreak early warning effective Efficiency Environmental surveillance Epidemiology first positive First wave flat Frequency house Hungary indicated infections introduced low frequency membrane N gene outbreak pandemic plant quantified reproducibility RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA second wave sewage subsequent Surveillance Treatment Viral load Volume wastewater Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2021.147398 PMC 바로가기 [Article Type] Article